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Naltrexone, approved in 1984, introduced a non-opioid antagonist that blocked the effects of opioids but required full detoxification before initiation, limiting its early use

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Once disc material is removed, it does not regenerate

For comparison, sulfasalazine (50 mg/kg intraperitoneally, once daily) (moderately effective) or 6--methylprednisolone (1.0 mg/kg intraperitoneally, once daily) (aggravation) was given